Heart disease and cancer are the two main causes of death worldwide. Cancer studies have largely focused on genetic factors and chemical signalling between the cancer cells, while cardiac studies have traditionally considered the mechanical response of the heart as a whole. Yet the mechanical and chemical environments must be linked.
A key issue that hinders progress is the lack of a multi-scale soft tissue models for heart diseases and cancers. Using new data, SofTMech will elucidate the chain of events from mechanical factors at a subcellular level to cell and tissue responses in healthy and diseased states, developing a multi-scale mathematical framework for soft tissue mechanics.
SofTMech will not only boost current heart and cancer research outputs; our approach will also contribute to a wide range of healthcare applications in soft tissues such as tendon, brain, skin, bladder, lung and gut.