WP1

WP1

 Mechanical Model of whole Cell

The aim of the research is to develop novel constitutive laws and multiscale models of cytoskeletal network dynamics. 

Project 1: We will develop a type of free energy function to describe a whole cell by including the fibre (actin) dispersion, various filaments within the cell cytoskeleton and other constituents (e.g. the nucleus), viscoelastic properties of the cell, and the cell membrane. 

Project 2: We will also extend the cell model to describe how mechanical and chemical stimuli influence protein expression and thus cell functionality and Growth&Remodelling of the extracellular matrix (thorough interaction with WP2) for matrix remodelling post myocardial infarction and cancer invasion.

 

Team: Prof.Ogden (leader), Dr. Yin, Prof. Olson, Prof. Chaplain, Prof. Insall, Prof. Husiemer, Prof. Luo, PDRA1, PhD1