Mechanobiological Models of Cell-Cell and Cell-ECM interactions
The tissue microenvironment influences cell functionality. How cells maintain and remodel the extracellular matrix (ECM) is vitally important both for tissue homeostasis and for pathological scenarios such as tumour growth, cancer invasion and myocardial infarction (MI).
Project 1: We will adopt an individual-based, force-based modelling approach to investigate cell-cell, cell-fibre and cell-ECM interactions using our multiscale-multicompartment model.
Project2: By taking into account the results of WP1 concerning the biomechanical properties of the cells and including the effect of actin and integrins on cell-ECM adhesion, we will develop a new system of intracellular ODEs governing these dynamics.
Project3: model extension through computational upscalling
Project4: Development of a fully 3D multiscale computational model of a growing, invading cell mass, which will be applied to the specific cases of breast cancer through WP6
Team: Prof. Chaplain (Team leader), Dr. McDougall, Prof. Ogden, Dr. Yin, Prof. Olson, Prof. Insall,
Prof. Husmeier, Prof. Luo, PDRA2, PhD2, PhD3