Multiscale heart modelling - Myocardial Infarction (MI)
Acute MI and remodelling in the heart is a highly complex process, involving pathophysiology, electrophysiology and multiphysics. Developing a multiscale heart model to cover all the aspects is unrealistic, hence we will provide key components with detailed myocardium mechanical models that are linked to subcellular organelle remodelling, as well as developing an extensible multiscale framework. We will significantly extend the open-source immersed boundary /finite element (IB/FE) fluid-structure interaction (FSI) framework (note: add a link under IB/FE to https://github.com/IBAMR/IBAMR).
Project 1: IB/FE multiscale rabbit acute-MI model
Project 2: IB/FE with electromechanical coupling
Project 3: Multi-scale Mechanobiological Model of MI
Project 4: Influence of angiogenesis on MI remodelling
Project 5: A multiscale human MI model
Project 6: Translation to healthcare Technologies by working closely with industrial partners.
Team: Prof. Luo, Prof. Ogden, Dr. McDougall, Prof. Hill, Prof. Smith, Prof. Berry, Dr. Watton, Dr. Radostin Simitev, Prof. Chaplain, Prof. Husmeier, Dr. Gao, PhD6, PhD7